CAPÍTULO 1
Allen, L. H. (2025). Micronutrients-Assessment, Requirements, Deficiencies, and Interventions. New England Journal of Medicine, 392(10), 1006–1016.
Albarqouni, L., Palagama, S., Chai, J., Sivananthajothy, P., Pathirana, T., Bakhit, M., … y Moynihan, R. (2022). Overuse of medications in low-and middle-income countries: a scoping review. Bulletin of the World Health Organization, 101(1), 36.
Baker, L. D., Espeland, M. A., Whitmer, R. A., Snyder, H. M., Leng, X., Lovato, L., … y Carrillo, M. C. (2025). Structured vs self-guided multidomain lifestyle interventions for global cognitive function: the US POINTER randomized clinical trial. JAMA, 334(8), 681–691.
Firth, J., Siddiqi, N., Koyanagi, A. I., Siskind, D., Rosenbaum, S., Galletly, C., … y Stubbs, B. (2019). The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness. The Lancet Psychiatry, 6(8), 675–712.
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., … y Slavich, G. M. (2019). Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 25(12), 1822–1832.
Gurven, M., Blackwell, A. D., Rodríguez, D. E., Stieglitz, J., y Kaplan, H. (2012). Does blood pressure inevitably rise with age? Longitudinal evidence among foragerhorticulturalists. Hypertension, 60(1), 25–33.
Gurven, M. D., y Lieberman, D. E. (2020). WEIRD bodies: mismatch, medicine and missing diversity. Evolution and Human Behavior, 41(5), 330–340.
Hepatology, T. L. G. (2024). Herbal and dietary supplements: unregulated hepatotoxicity. The Lancet Gastroenterology & Hepatology, 9(11), 965.
Kaplan, H., Thompson, R. C., Trumble, B. C., Wann, L. S., Allam, A. H., Beheim, B., … y Thomas, G. S.
(2017). Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study. The Lancet, 389(10080), 1730–1739.
Li, Y., Schoufour, J., Wang, D. D., Dhana, K., Pan, A., Liu, X., … y Hu, F. B. (2020). Healthy lifestyle and life expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study. British Medical Journal, 368, l6669.
Lieberman, D. E., Kistner, T. M., Richard, D., Lee, I. M., y Baggish, A. L. (2021). The active grandparent hypothesis: Physical activity and the evolution of extended human healthspans and lifespans. Proceedings of the National Academy of Sciences USA, 118(50), e2107621118.
Luciano, M., Sampogna, G., D’Ambrosio, E., Rampino, A., Amore, M., Calcagno, P., … y Fiorillo, A. (2024). One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial. European Archives of Psychiatry and Clinical Neuroscience, 274(4), 903–915.
Momen, N. C., Plana-Ripoll, O., Agerbo, E., Benros, M. E., Børglum, A. D., Christensen, M. K., … y McGrath, J. J. (2020). Association between mental disorders and subsequent medical conditions. New England Journal of Medicine, 3--82(18), 1721–1731.
Naghavi, M., Kyu, H. H., Aalipour, M. A., Aalruz, H., Ababneh, H. S., Abafita, B. J., … y Al Homsi,
A. (2025). Global burden of 292 causes of death in 204 countries and territories and 660 subnational
locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023. The Lancet, 406(10513), 1811-1872.
Nyberg, S. T., Singh-Manoux, A., Pentti, J., Madsen, I. E., Sabia, S., Alfredsson, L., … y Kivimäki, M. (2020). Association of healthy lifestyle with years lived without major chronic diseases. JAMA Internal Medicine, 180(5), 760–768.
Ornish, D., Scherwitz, L. W., Billings, J. H., Gould, K. L., Merritt, T. A., Sparler, S., …y Brand, R. J. (1998). Intensive lifestyle changes for reversal of coronary heart disease. JAMA, 280(23), 2001–2007.
Pontzer, H., Wood, B. M., y Raichlen, D. A. (2018). Hunter‐gatherers as models in public health. Obesity Reviews, 19, 24–35.
Raitakari, O., Pahkala, K., y Magnussen, C. G. (2022). Prevention of atherosclerosis from childhood. Nature Reviews Cardiology, 19(8), 543–554.
Rippe, J. M. (2018). Lifestyle medicine: the health promoting power of daily habits and practices. American Journal of Lifestyle Medicine, 12(6), 499–512.
Rosenfeld, R. M., Grega, M. L., Karlsen, M. C., Abu Dabrh, A. M., Aurora, R. N., Bonnet, J. P., … y Gulati,
M. (2025). Lifestyle interventions for treatment and remission of type 2 diabetes and prediabetes in adults: a clinical practice guideline from the American College of Lifestyle Medicine. American Journal of Lifestyle Medicine, 19(2_suppl), 10S–131S.
Sayre, M. K., Pontzer, H., Alexander, G. E., Wood, B. M., Pike, I. L., Mabulla, A. Z., y Raichlen, D. A.
(2020). Ageing and physical function in East African foragers and pastoralists. Philosophical Transactions of the Royal Society B, 375(1811), 20190608.
Thomas, W. A., Davies, J. N., O’Neal, R. M., y Dimakulangan, A. A. (1960). Incidence of myocardial infarction correlated with venous and pulmonary thrombosis and embolism: A geographic study based on autopsies in Uganda, East Africa and St. Louis, USA. American Journal of Cardiology, 5(1), 41–47.
Yirmiya, R. (2024). The inflammatory underpinning of depression: An historical perspective. Brain, Behavior, and Immunity, 122, 433–443.
Zeng, Y., Chourpiliadis, C., Hammar, N., Seitz, C., Valdimarsdóttir, U. A., Fang, F., … y Wei, D. (2024). Inflammatory biomarkers and risk of psychiatric disorders. JAMA Psychiatry, 81(11), 1118–1129.
Zhao, Y., Yang, L., Sahakian, B. J., Langley, C., Zhang, W., Kuo, K., … y Cheng, W. (2023). The brain structure, immunometabolic and genetic mechanisms underlying the association between lifestyle and depression. Nature Mental Health, 1(10), 736–750.
CAPÍTULO 2
Agorastos, A., & Chrousos, G. P. (2022). The neuroendocrinology of stress: the stress-related continuum of chronic disease development. Molecular Psychiatry, 27(1), 502-513.
Balanos, G. M., Phillips, A. C., Frenneaux, M. P., McIntyre, D., Lykidis, C., Griffin, H. S., y Carroll, D.
(2010). Metabolically exaggerated cardiac reactions to acute psychological stress: the effects of resting blood pressure status and possible underlying mechanisms. Biological Psychology, 85(1), 104–111.
Balban, M. Y., Neri, E., Kogon, M. M., Weed, L., Nouriani, B., Jo, B., … y Huberman, A. D. (2023). Brief structured respiration practices enhance mood and reduce physiological arousal. Cell Reports Medicine, 4(1),100895.
Bobba-Alves, N., Juster, R. P., y Picard, M. (2022). The energetic cost of allostasis and allostatic load. Psychoneuroendocrinology, 146, 105951.
Bratman, G. N., Anderson, C. B., Berman, M. G., Cochran, B., De Vries, S., Flanders, J., … y Daily, G. C. (2019). Nature and mental health: An ecosystem service perspective. Science Advances, 5(7), eaax0903.
Cain, T., Brinsley, J., Bennett, H., Nelson, M., Maher, C., y Singh, B. (2025). Effects of cold-water immersion on health and wellbeing: A systematic review and metaanalysis. PLOS One, 20(1), e0317615.
Chen, W. G., Schloesser, D., Arensdorf, A. M., Simmons, J. M., Cui, C., Valentino, R., … y Langevin, H. M. (2021). The emerging science of interoception: sensing, integrating, interpreting, and regulating signals within the self. Trends in Neurosciences, 44(1), 3–16.
Damasio, A., y Carvalho, G. B. (2013). The nature of feelings: evolutionary and neurobiological origins. Nature Reviews Neuroscience, 14(2), 143–152. Fedurek, P., Lehmann, J., Lacroix, L., Aktipis, A., Cronk, L., Makambi, E. J., … y Berbesque, J. C. (2023). Status does not predict stress among Hadza hunter-gatherer men. Scientific Reports, 13(1), 1327.
Feldman, M. J., Bliss-Moreau, E., y Lindquist, K. A. (2024). The neurobiology of interoception and affect. Trends in Cognitive Sciences, 28(7), 643–661.
Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., y Marks, J. S. (1998). Rela-tionship of childhood abuse and household dysfunction to many of the leading causes of death in adults: The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine, 14(4), 245–258.
Grotzinger, A. D., Werme, J., Peyrot, W. J., Frei, O., de Leeuw, C., Bicks, L. K., … y Smoller, J. W. (2025). Mapping the genetic landscape across 14 psychiatric disorders. Nature, 649, 406–415.
Hughes, K., Bellis, M. A., Hardcastle, K. A., Sethi, D., Butchart, A., Mikton, C., ... y Dunne, M. P. (2017). The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis. The Lancet Public Health, 2(8), e356–e366.
Kelley, D. P., Singleton, S. P., Venable, K., Sturm, G., Skovgaard, A., Francis, J., … y O’Donovan, A. (2025). The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms. Neuroscience & Biobehavioral Reviews, 179, 106419.
Kivimäki, M., Bartolomucci, A., y Kawachi, I. (2023). The multiple roles of life stress in metabolic disorders. Nature Reviews Endocrinology, 19(1), 10–27.
Kleckner, I. R., Zhang, J., Touroutoglou, A., Chanes, L., Xia, C., Simmons, W. K., ... y Feldman Barrett, L. (2017). Evidence for a large-scale brain system supporting allostasis and interoception in humans. Nature Human Behaviour, 1(5), 0069.
Nelson, C. A., Sullivan, E. F., y Valdes, V. (2025). Early adversity alters brain architecture and increases susceptibility to mental health disorders. Nature Reviews Neuroscience, 26(10), 642–656.
Nesse, R. M. (2019). The smoke detector principle: signal detection and optimal defense regulation. Evolution, Medicine, and Public Health, 2019(1), 1–1.
Nesse, R. M. (2023). Evolutionary psychiatry: foundations, progress and challenges. World Psychiatry, 22(2), 177–202.
Nord, C. L., y Garfinkel, S. N. (2022). Interoceptive pathways to understand and treat mental health conditions. Trends in Cognitive Sciences, 26(6), 499–513.
Plana-Ripoll, O., Pedersen, C. B., Holtz, Y., Benros, M. E., Dalsgaard, S., De Jonge, P., ... y McGrath, J. J. (2019). Exploring comorbidity within mental disorders among a Danish national population. JAMA Psychiatry, 76(3), 259–270.
Rakers, F., Rupprecht, S., Dreiling, M., Bergmeier, C., Witte, O. W., y Schwab, M. (2020). Transfer of maternal psychosocial stress to the fetus. Neuroscience & Biobehavioral Reviews, 117, 185–197.
Santamaría-García, H., Migeot, J., Medel, V., Hazelton, J. L., Teckentrup, V., Romero-Ortuno, R., ... y Ibanez, A. (2025). Allostatic interoceptive overload across psychiatric and neurological conditions. Biological Psychiatry, 97(1), 28-40.
Schulkin, J., y Sterling, P. (2019). Allostasis: a brain-centered, predictive mode of physiological regulation. Trends in Neurosciences, 42(10), 740–752.
Simon, N. M., Hofmann, S. G., Rosenfield, D., Hoeppner, S. S., Hoge, E. A., Bui, E., y Khalsa, S. B. S. (2021). Efficacy of yoga vs cognitive behavioral therapy vs stress education for the treatment of generalized anxiety disorder: a randomized clinical trial. JAMA Psychiatry, 78(1), 13–20.
Sterling, P., y Laughlin, S. (2023). Why an animal needs a brain. Animal Cognition, 26(6), 1751–1762.
Torre, J. B., y Lieberman, M. D. (2018). Putting feelings into words: Affect labeling as implicit emotion regulation. Emotion Review, 10(2), 116–124.
CAPÍTULO 3
Boivin, D. B., Boudreau, P., y Kosmadopoulos, A. (2022). Disturbance of the circadian system in shift work and its health impact. Journal of Biological Rhythms, 37(1), 3–28.
Brodt, S., Inostroza, M., Niethard, N., y Born, J. (2023). Sleep—A brain-state serving systems memory consolidation. Neuron, 111(7), 1050–1075.
Cartwright, R. D., Lloyd, S., Knight, S., y Trenholme, I. (1984). Broken dreams: A study of the effects of divorce and depression on dream content. Psychiatry, 47(3), 251–259.
Chellappa, S. L. (2021). Individual differences in light sensitivity affect sleep and circadian rhythms. Sleep, 44(2), zsaa214.
Depner, C. M., Melanson, E. L., Eckel, R. H., Snell-Bergeon, J. K., Perreault, L., Bergman, B. C., ... y Wright, K. P. (2019). Ad libitum weekend recovery sleep fails to prevent metabolic dysregulation during a repeating pattern of insufficient sleep and weekend recovery sleep. Current Biology, 29(6), 957–967.
El Rafihi-Ferreira, R., Hasan, R., Toscanini, A. C., Linares, I. M., Suzuki Borges, D., Brasil, I. P., ... y Morin, C. (2024). Acceptance and commitment therapy versus cognitive behavioral therapy for insomnia: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 92(6), 330.
Freeman, D., Sheaves, B., Waite, F., Harvey, A. G., y Harrison, P. J. (2020). Sleep disturbance and psychiatric disorders. The Lancet Psychiatry, 7(7), 628–637.
Gardiner, C. L., Weakley, J., Burke, L. M., Fernandez, F., Johnston, R. D., Leota, J., ... y Halson, S. L. (2025). Dose and timing effects of caffeine on subsequent sleep: a randomized clinical crossover trial. Sleep, 48(4), zsae230.
Hablitz, L. M., y Nedergaard, M. (2021). The glymphatic system: a novel component of fundamental neurobiology. Journal of Neuroscience, 41(37), 7698–7711.
Hastings, M. H., Maywood, E. S., y Brancaccio, M. (2018). Generation of circadian rhythms in the suprachiasmatic nucleus. Nature Reviews Neuroscience, 19(8), 453–469.
Hirshkowitz, M., Whiton, K., Albert, S. M., Alessi, C., Bruni, O., DonCarlos, L., ... y Hillard, P. J. A. (2015).
National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health, 1(1), 40–43.
Irwin, M. R. (2019). Sleep and inflammation: partners in sickness and in health. Nature Reviews Immunology, 19(11), 702–715.
Jiao, Y., Butoyi, C., Zhang, Q., Intchasso Adotey, S. A. A., Chen, M., Shen, W., ... y Jia, J. (2025). Sleep disorders impact hormonal regulation: unravelling the relationship among sleep disorders, hormones and metabolic diseases. Diabetology & Metabolic Syndrome, 17(1), 305.
Klinzing, J. G., Niethard, N., y Born, J. (2019). Mechanisms of systems memory consolidation during sleep. Nature Neuroscience, 22(10), 1598–1610.
Krause, A. J., Simon, E. B., Mander, B. A., Greer, S. M., Saletin, J. M., Goldstein-Piekarski, A. N., y Walker, M. P. (2017). The sleep-deprived human brain. Nature Reviews Neuroscience, 18(7), 404–418.
Lam, R. W., Levitt, A. J., Levitan, R. D., Michalak, E. E., Cheung, A. H., Morehouse, R., ... y Tam, E. M. (2016). Efficacy of bright light treatment, fluoxetine, and the combination in patients with nonseasonal major depressive disorder: a randomized clinical trial. JAMA Psychiatry, 73(1), 56–63.
Leadbeater, E., y Watrobska, C. (2025). What could evolve in the evolution of memory? Philosophical Transactions of the Royal Society B, 380(1929), 20240109.
Lim, D. C., Najafi, A., Afifi, L., Bassetti, C. L., Buysse, D. J., Han, F., ... y Jackson, C. L. (2023). The need to promote sleep health in public health agendas across the globe. The Lancet Public Health, 8(10), e820–e826.
Logan, R. W., y McClung, C. A. (2019). Rhythms of life: circadian disruption and brain disorders across the lifespan. Nature Reviews Neuroscience, 20(1), 49–65.
Medic, G., Wille, M., y Hemels, M. E. (2017). Short-and long-term health consequences of sleep disruption. Nature and Science of Sleep, 9, 151–161.
Nakamura, N., Akiyama, H., Nishimura, M., Zhu, K., Suzuki, K., Higuchi, M., y Tanisawa, K. (2023). Acute social jetlag augments morning blood pressure surge: a randomized crossover trial. Hypertension Research, 46(9), 2179–2191.
Nedergaard, M., y Goldman, S. A. (2020). Glymphatic failure as a final common pathway to dementia. Science, 370(6512), 50–56.
Pan, Z., Huang, M., Huang, J., Yao, Z., y Lin, Z. (2020). Association of napping and all-cause mortality and incident cardiovascular diseases: a dose–response meta analysis of cohort studies. Sleep Medicine, 74, 165–172.
Prather, A. A., Janicki-Deverts, D., Hall, M. H., y Cohen, S. (2015). Behaviorally assessed sleep and susceptibility to the common cold. Sleep, 38(9), 1353–1359.
Samson, D. R., Clerget, A., Abbas, N., Senese, J., Sarma, M. S., Lew-Levy, S., ... y Perogamvros, L. (2023). Evidence for an emotional adaptive function of dreams: a cross-cultural study. Scientific Reports, 13(1), 16530.
Samson, D. R., Crittenden, A. N., Mabulla, I. A., Mabulla, A. Z., y Nunn, C. L. (2017). Chronotype variation drives night-time sentinel-like behaviour in hunter–gatherers. Proceedings of the Royal Society B: Biological Sciences, 284(1858), 20170967.
Sletten, T. L., Weaver, M. D., Foster, R. G., Gozal, D., Klerman, E. B., Rajaratnam, S. M., ... y Czeisler, C. A. (2023). The importance of sleep regularity: a consensus statement of the National Sleep Foundation sleep timing and variability panel. Sleep Health, 9(6), 801–820.
Windred, D. P., Burns, A. C., Lane, J. M., Saxena, R., Rutter, M. K., Cain, S. W., y Phillips, A. J. (2024). Sleep regularity is a stronger predictor of mortality risk than sleep duration: a prospective cohort study. Sleep, 47(1), zsad253.
CAPÍTULO 4
Baker, P., Slater, S., White, M., Wood, B., Contreras, A., Corvalán, C., ... y Barquera, S. (2025). Towards unified global action on ultra-processed foods: understanding commercial determinants, countering corporate power, and mobilising a public health response. The Lancet, 406(10520), 2703-2726.
Barr, W. A., Pobiner, B., Rowan, J., Du, A., y Faith, J.
T. (2022). No sustained increase in zooarchaeological evidence for carnivory after the appearance of Homo erectus. Proceedings of the National Academy of Sciences USA, 119(5), e2115540119.
Barrett, T. S., Hafermann, J. O., Richards, S., LeJeune, K., y Eid, G. M. (2025). Obesity treatment with bariatric surgery vs GLP-1 receptor agonists. JAMA Surgery, 160(11), 1232-1239.
Blüher, M. (2019). Obesity: global epidemiology and pathogenesis. Nature Reviews Endocrinology, 15(5), 288-298.
Dyble, M., Thompson, J., Smith, D., Salali, G. D.,
Chaudhary, N., Page, A. E., ... y Migliano, A. B. (2016). Networks of food sharing reveal the functional significance of multilevel sociality in two hunter-gatherer groups. Current Biology, 26(15), 2017-2021.
Fackelmann, G., Manghi, P., Carlino, N., Heidrich, V., Piccinno, G., Ricci, L., ... y Segata, N. (2025).
Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals. Nature Microbiology, 10(1), 41-52.
Fan, Y., y Pedersen, O. (2021). Gut microbiota in human metabolic health and disease. Nature Reviews Microbiology, 19(1), 55-71.
Fülling, C., Dinan, T. G., y Cryan, J. F. (2019). Gut microbe to brain signaling: what happens in vagus. Neuron, 101(6), 998-1002.
Gearhardt, A. N., y Schulte, E. M. (2021). Is food addictive? A review of the science. Annual Review of Nutrition, 41(1), 387-410.
Hall, K. D., Ayuketah, A., Brychta, R., Cai, H.,
Cassimatis, T., Chen, K. Y., ... y Zhou, M. (2019). Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake. Cell Metabolism, 30(1), 67-77.
Hall, K. D., Guo, J., Courville, A. B., Boring, J.,
Brychta, R., Chen, K. Y., ... y Chung, S. T. (2021). Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake. Nature Medicine, 27(2), 344-353.
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., ... y Pettersson, S. (2011). Normal gut microbiota modulates brain development and behavior. Proceedings of the National Academy of Sciences USA, 108(7), 3047-3052.
Joos, R., Boucher, K., Lavelle, A., Arumugam, M., Blaser, M. J., Claesson, M. J., ... y Ross, R. P. (2025). Examining the healthy human microbiome concept. Nature Reviews Microbiology, 23(3), 192-205.
Juul, F., Martinez-Steele, E., Parekh, N., y Monteiro, C.
A. (2025). The role of ultra-processed food in obesity.
Nature Reviews Endocrinology, 21(11), 672-685.
Kearns, C. E., Schmidt, L. A., y Glantz, S. A. (2016). Sugar industry and coronary heart disease research:
a historical analysis of internal industry documents.
JAMA Internal Medicine, 176(11), 1680-1685.
Kraft, T. S., Venkataraman, V. V., Wallace, I. J., Crittenden, A. N., Holowka, N. B., Stieglitz, J., ... y Pontzer, H. (2021). The energetics of uniquely human subsistence strategies. Science, 374(6575), eabf0130.
López-Moreno, M., Fresán, U., Marchena-Giráldez, C., Bertotti, G., y Roldán-Ruiz, A. (2025). Industry study sponsorship and conflicts of interest on the effect of unprocessed red meat on cardiovascular disease risk: a systematic review of clinical trials. American Journal of Clinical Nutrition, 121(6), 1246-1257.
Melamed, Y., Kislev, M. E., Geffen, E., Lev-Yadun, S., y Goren-Inbar, N. (2016). The plant component of an Acheulian diet at Gesher Benot Ya ‘aqov, Israel. Proceedings of the National Academy of Sciences USA, 113(51), 14674-14679.
Monteiro, C. A., Louzada, M. L., Steele-Martinez, E., Cannon, G., Andrade, G. C., Baker, P., ... y
Touvier, M. (2025). Ultra-processed foods and human health: the main thesis and the evidence. The Lancet, 406(10520), 2667-2684.
Pagidipati, N. J., Taub, P. R., Ostfeld, R. J., y Kirkpatrick, C. F. (2025). Dietary patterns to promote cardiometabolic health. Nature Reviews Cardiology, 22(1), 38-46.
Pontzer, H., y Wood, B. M. (2021). Effects of evolution, ecology, and economy on human diet: insights from hunter-gatherers and other small-scale societies. Annual Review of Nutrition, 41(1), 363-385.
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J.,
Duncan, A. E., Kau, A. L., ... y Gordon, J. I. (2013). Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science, 341(6150), 1241214.
Rubino, F., Cummings, D. E., Eckel, R. H., Cohen,
R. V., Wilding, J. P., Brown, W. A., ... y Mingrone, G. (2025). Definition and diagnostic criteria of clinical obesity. The Lancet Diabetes & Endocrinology, 13(3), 221-262.
Rubino, F., Puhl, R. M., Cummings, D. E., Eckel, R.
H., Ryan, D. H., Mechanick, J. I., ... y Dixon, J. B. (2020). Joint international consensus statement for ending stigma of obesity. Nature Medicine, 26(4), 485-497.
Sonnenburg, J. L., y Sonnenburg, E. D. (2019). Vulnerability of the industrialized microbiota. Science, 366(6464), eaaw9255.
Tessier, A. J., Wang, F., Korat, A. A., Eliassen, A. H., Chavarro, J., Grodstein, F., ... y Guasch-Ferré, M. (2025). Optimal dietary patterns for healthy aging. Nature Medicine, 31(5), 1644-1652.
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., y Gordon, J. I. (2006). An obesity-associated gut microbiome with increased capacity for energy harvest. Nature, 444(7122), 1027-1031.
Valenzuela, P. L., Carrera-Bastos, P., Castillo-García, A., Lieberman, D. E., Santos-Lozano, A., y Lucia,
A. (2023). Obesity and the risk of cardiometabolic diseases. Nature Reviews Cardiology, 20(7), 475-494.
Weyrich, L. S., Duchene, S., Soubrier, J., Arriola, L., Llamas, B., Breen, J., ... y Cooper, A. (2017). Neander-thal behaviour, diet, and disease inferred from ancient DNA in dental calculus. Nature, 544(7650), 357-361.
Wu, Y., Ehlert, B., Metwally, A. A., Perelman, D., Park, H., Brooks, A. W., ... y Snyder, M. P. (2025). Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology. Nature Medicine, 31(7), 2232-2243.
CAPÍTULO 5
Araújo, C. G. S., Kunutsor, S. K., Eijsvogels, T. M., Myers, J., Laukkanen, J. A., Hamar, D., ... y Castro, C. L. B. (2025). Muscle Power Versus Strength as a Predictor of Mortality in Middle-Aged and Older Men and Women. Mayo Clinic Proceedings, 100(8), 1319-1331.
Booth, F. W., Roberts, C. K., Thyfault, J. P., Ruegsegger, G. N., y Toedebusch, R. G. (2017). Role of inactivity in chronic diseases: evolutionary insight and pathophysiological mechanisms. Physiological Reviews, 97(4), 1351-1402.
Brill, G., Mirazon-Lahr, M., y Dyble, M. (2024). Extensive locomotor versatility across a global sample of hunter–gatherer societies. Proceedings of the Royal Society B: Biological Sciences, 291(2036), 20242553.
Bull, F. C., Al-Ansari, S. S., Biddle, S., Borodulin, K., Buman, M. P., Cardon, G., ... y Willumsen, J. F. (2020). World Health Organization 2020 guidelines on physical activity and sedentary behaviour. British Journal of Sports Medicine, 54(24), 1451-1462.
Contrepois, K., Wu, S., Moneghetti, K. J., Hornburg, D., Ahadi, S., Tsai, M. S., ... y Snyder, M. P. (2020). Molecular choreography of acute exercise. Cell, 181(5), 1112-1130.
Cruz-Jentoft, A. J., y Sayer, A. A. (2019). Sarcopenia. The Lancet, 393(10191), 2636-2646.
Ding, D., Nguyen, B., Nau, T., Luo, M., del Pozo Cruz, B., Dempsey, P. C., ... y Owen, K. (2025). Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis. The Lancet Public Health, 10(8), e668-e681.
Ekelund, U., Tarp, J., Ding, D., Sanchez-Lastra, M. A., Dalene, K. E., Anderssen, S. A., ... y Fagerland, M. W. (2026). Deaths potentially averted by small changes in physical activity and sedentary time: an individual participant data meta-analysis of prospective cohort studies. The Lancet, 407(10526):339-349.
Fink, B., Bläsing, B., Ravignani, A., y Shackelford, T. K. (2021). Evolution and functions of human dance. Evolution and Human Behavior, 42(4), 351-360.
Freitas, S. R., Cruz-Montecinos, C., Ratel, S., y Pinto, R. S. (2024). Powerpenia should be considered a biomarker of healthy aging. Sports Medicine-Open, 10(1), 27.
Han, M., Qie, R., Shi, X., Yang, Y., Lu, J., Hu, F., ... y Zhao, Y. (2022). Cardiorespiratory fitness and mortality from all causes, cardiovascular disease and cancer: dose–response meta-analysis of cohort studies. British Journal of Sports Medicine, 56(13), 733-739.
Islam, H., Gibala, M. J., yLittle, J. P. (2022). Exercise snacks: a novel strategy to improve cardiometabolic health. Exercise and Sport Sciences Reviews, 50(1), 31-37.
Jeong, S. W., Kim, S. H., Kang, S. H., Kim, H. J., Yoon, C. H., Youn, T. J., y Chae, I. H. (2019). Mortality reduction with physical activity in patients with and without cardiovascular disease. European Heart Journal, 40(43), 3547-3555.
Kjaer, M., Secher, N. H., Bangsbo, J., Perko, G., Horn, A., Mohr, T., y Galbo, H. (1996). Hormonal and metabolic responses to electrically induced cycling during epidural anesthesia in humans. Journal of Applied Physiology, 80(6), 2156-2162.
Kokkinos, P., Faselis, C., Samuel, I. B. H., Pittaras, A., Doumas, M., Murphy, R., ... y Myers, J. (2022). Cardiorespiratory fitness and mortality risk across the spectra of age, race, and sex. Journal of the American College of Cardiology, 80(6), 598-609.
Lecka-Czernik, B., Rosen, C. J., y Napoli, N. (2025). The role of bone in whole-body energy metabolism. Nature Reviews Endocrinology, 21(12), 743-756.
Lieberman, D. E. (2015). Is exercise really medicine? An evolutionary perspective. Current Sports Medicine Reports, 14(4), 313-319.
Moolyk, A. N., Wilson, M. K., Matenchuk, B. A., Bains, G., Gervais, M. J., Wowdzia, J. B., y Davenport, M. H. (2025). Maternal and fetal responses to acute high-intensity resistance exercise during pregnancy. British Journal of Sports Medicine, 59(3), 159-166.
Moore, D. R., Williamson, E. P., Hodson, N., Estafanos, S., Mazzulla, M., Kumbhare, D., y Gillen, J. B. (2022). Walking or body weight squat “activity snacks” increase dietary amino acid utilization for myofibrillar protein synthesis during prolonged sitting. Journal of Applied Physiology, 133(3), 777-785.
Morin, S. N., Leslie, W. D., y Schousboe, J. T. (2025). Osteoporosis: a review. JAMA, 334(10):894-907.
Nishikori, S., Yasuda, J., Murata, K., Takegaki, J., Harada, Y., Shirai, Y., y Fujita, S. (2023). Resistance training rejuvenates aging skin by reducing circulating inflammatory factors and enhancing dermal extracellular matrices. Scientific Reports, 13(1), 10214.
Noetel, M., Sanders, T., Gallardo-Gómez, D., Taylor, P., del Pozo Cruz, B., Van Den Hoek, D., ... y Lonsdale, C. (2024). Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials. British Medical Journal, 384, e075847.
O’Sullivan, P. B., Caneiro, J. P., O’Sullivan, K., Lin, I., Bunzli, S., Wernli, K., y O’Keeffe, M. (2020). Back to basics: 10 facts every person should know about back pain. British Journal of Sports Medicine, 54(12), 698-699.
Pisor, A. C., Gurven, M., Blackwell, A. D., Kaplan, H., y Yetish, G. (2013). Patterns of senescence in human cardiovascular fitness: VO2max in subsistence and industrialized populations. American Journal of Human Biology, 25(6), 756-769.
Raghuveer, G., Hartz, J., Lubans, D. R., Takken, T., Wiltz, J. L., Mietus-Snyder, M., ... y American Heart Association Young Hearts Athero, Hypertension and Obesity in the Young Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young. (2020). Cardiorespiratory fitness in youth: an important marker of health: a scientific statement from the American Heart Association. Circulation, 142(7), e101-e118.
Raichlen, D. A., y Lieberman, D. E. (2022). The evolution of human step counts and its association with the risk of chronic disease. Current Biology, 32(21), R1206-R1214.
Raichlen, D. A., Pontzer, H., Zderic, T. W., Harris, J. A., Mabulla, A. Z., Hamilton, M. T., y Wood, B. M. (2020). Sitting, squatting, and the evolutionary biology of human inactivity. Proceedings of the National Academy of Sciences USA, 117(13), 7115-7121.
Sallis, R., Young, D. R., Tartof, S. Y., Sallis, J. F., Sall, J., Li, Q., ... y Cohen, D. A. (2021). Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients. British Journal of Sports Medicine, 55(19), 1099-1105.
Sayre, M. K., Anyawire, M., Paolo, B., Mabulla, A. Z., Pontzer, H., Wood, B. M., y Raichlen, D. A. (2023). Lifestyle and patterns of physical activity in Hadza foragers. American Journal of Biological Anthropology, 182(3), 340-356.
Schmitz, K. H., Campbell, A. M., Stuiver, M. M., Pinto, B. M., Schwartz, A. L., Morris, G. S., ... y Matthews, C. E. (2019). Exercise is medicine in oncology: engaging clinicians to help patients move through cancer. CA: a cancer journal for clinicians, 69(6), 468-484.
Severinsen, M. C. K., y Pedersen, B. K. (2020). Muscle–organ crosstalk: the emerging roles of myokines. Endocrine Reviews, 41(4), 594-609.
Tari, A. R., Walker, T. L., Huuha, A. M., Sando, S. B., y Wisloff, U. (2025). Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing. The Lancet, 405(10484), 1093-1118.
